Selected Journal Articles

M. Lopez-Cavestany, O. Wright, A. Cassidy, A. Carter, M. King; Dual Affinity Nanoparticles for the Transport of Therapeutics from Carrier Cells to Target Cells under Physiological Flow Conditions. ACS Omega. 2023. 8 (45).

J. Hope, J. Dombroski, R. Pereles, et al.; Fluid shear stress enhances T cell activation through Piezo1. BMC Biology 20, 2022. 61.

J. Greenlee, T. Subramanian, K. Liu, M. King; Rafting Down the Metastatic Cascade: The Role of Lipid Rafts in Cancer Metastasis, Cell Death, and Clinical Outcomes. Cancer Res 1. 2016. 81 (1): 5–17.

E. Wayne, S Chandrasekaran, M. Mitchell, M. Chan, R. Lee, C. Schaffer, M. King; TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer. Journal of Controlled Release. 2016. 223:215-23.

S. Chandrasekaran, M. Chan, J. Li, M. King; Super natural killer cells that target metastases in the tumor draining lymph nodes. Biomaterials. 2016. 77:66-76.

M. Mitchell, E. Wayne, K. Rana, C. Schaffer, M. King; TRAIL-coated leukocytes that kill cancer cells in the circulation. Proceedings of the National Academy of Sciences of the USA. 2014. 111:930-5

For more publications, visit Dr. Michael R. King’s google scholar site!

Selected Patent Information

Dual Affinity Nanoparticles for the Treatment of Cancer

Fabrication of Superhydrophobic Microwell Arrays for Culture of 3D Cancer Models

While nanoparticle therapeutics show great promise in the treatment of cancer, there remain challenges in deploying this technology as a bona fide cancer therapy. To that end, Dr. Lopez-Cavestany spearheaded the development of a two-stage nanoparticle delivery platform relying on the dual functionalization of liposomes with moieties that have fundamentally different strengths of adhesion and binding kinetics to bind to a carrier cell (leukocyte) followed by the target cell (CTC)

Fabrication of Superhydrophobic Microwell Arrays for Culture of 3D Cancer Models

The goal of this project is to utilize nanolithography techniques to optimize and fabricate superhydrophobic, nanostructured surfaces within a microwell device to reliably grow 3D cancer models. Two different designs will be implicated as a proof of concept that the device can be used to reliably culture a spheroid model and a CTC model in vitro.