M. Lopez-Cavestany, O. Wright, N. Reckhorn, A. Carter, et al. Superhydrophobic Array Devices for the Enhanced Formation of 3D Cancer Models. ACS Nano. 2024. 18 (34).
J. Hope, J. Dombroski, R. Pereles, et al.; Fluid shear stress enhances T cell activation through Piezo1. BMC Biology 20, 2022. 61.
J. Greenlee, T. Subramanian, K. Liu, M. King; Rafting Down the Metastatic Cascade: The Role of Lipid Rafts in Cancer Metastasis, Cell Death, and Clinical Outcomes. Cancer Res 1. 2016. 81 (1): 5–17.
E. Wayne, S Chandrasekaran, M. Mitchell, M. Chan, R. Lee, C. Schaffer, M. King; TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer. Journal of Controlled Release. 2016. 223:215-23.
M. Mitchell, E. Wayne, K. Rana, C. Schaffer, M. King; TRAIL-coated leukocytes that kill cancer cells in the circulation. Proceedings of the National Academy of Sciences of the USA. 2014. 111:930-5
For more publications, visit Dr. Michael R. King’s google scholar site!
While nanoparticle therapeutics show great promise in the treatment of cancer, there remain challenges in deploying this technology as a bona fide cancer therapy. To that end, Dr. Lopez-Cavestany spearheaded the development of a two-stage nanoparticle delivery platform relying on the dual functionalization of liposomes with moieties that have fundamentally different strengths of adhesion and binding kinetics to bind to a carrier cell (leukocyte) followed by the target cell (CTC)
The goal of this project is to utilize nanolithography techniques to optimize and fabricate superhydrophobic, nanostructured surfaces within a microwell device to reliably grow 3D cancer models. Two different designs will be implicated as a proof of concept that the device can be used to reliably culture a spheroid model and a CTC model in vitro.